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doi: 10.1210/clinem/dgae583 81 KroghLLNielsenCKBergmannNCHolstJJLundAGasbjergLSet al

The individuals involved in MDL 2452 claim that the defendants willfully, wantonly, and with malice withheld the knowledge of an increased risk of pancreatic cancer in users of the Drugs to prevent any chances of their products registration being delayed or rejected by [the] FDA. The Complaint further alleges that: the defendants manufactured defective drugs which caused unreasonable and dangerous side effects, the defendants failed to conduct adequate research and test the incretin mimetic drugs before making them available on the market, the defendants failed to warn healthcare professionals and consumers of these potential side effects, even concealing the risks of pancreatitis and pancreatic cancer from the public, the manufacturers failed to include specific wordage, such as pancreatic cancer, on the drugs labels, and the plaintiffs allege that the current warnings for the drugs are still inadequate

We have previously proposed that the mode of action of liraglutide may involve inhibition of upper gastrointestinal motility resulting in a greater transit time of the luminal content, thus allowing more time for passive and transporter-mediated active absorption of bile acids in the small intestine (20,25) (Figure 2)