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This paper presents independent research supported by the National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre at the University Hospitals Birmingham NHS Foundation Trust and the University of Birmingham (grant reference number BRC121520009)

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The GLP-1 revolution, which started with relatively modest single-agonist drugs, has progressed to dual-agonists, then triple-agonists, and the pipeline continues to expand

Endpoints and assessments The primary endpoint was absolute change from baseline in body weight at week 48

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