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This chemosensor, together with other 27 non-selective cationic channels, is part of a larger family named transient receptor potential (TRP) channel superfamily and is known to play an important role in the metabolic syndrome (361, 362)

They demonstrate that prolonged (24 h) agonism with high dose (1 M) GIP does indeed elicit near complete functional desensitization of the receptor to secondary stimulation as measured by fatty-acid uptake in murine and human adipocytes

J Diabetes Investig 12(9):16421650

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Clinical evaluation should include comprehensive metabolic assessment with fasting glucose, hemoglobin A1C, lipid panel, and thyroid function tests

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