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GIP is the only additional substrate of note for glucose regulation and works in both humans (5, 167) and mice (66, 85) suggest that both GIP and GLP-1 signaling are targets for the improved glucose control with these drugs

Oxyntomodulin is an endogenous peptide secreted by the enteroendocrine cells of the intestine in response to oral nutrients, which acts as an agonist at both GLP-1 and glucagon receptors [40]

Guo et al., 2022)

Managing Muscle Loss and Supporting Metabolism One of the biggest concerns with rapid weight loss is muscle loss