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GIP is the only additional substrate of note for glucose regulation and works in both humans (5, 167) and mice (66, 85) suggest that both GIP and GLP-1 signaling are targets for the improved glucose control with these drugs

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Oxyntomodulin is an endogenous peptide secreted by the enteroendocrine cells of the intestine in response to oral nutrients, which acts as an agonist at both GLP-1 and glucagon receptors [40]

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Guo et al., 2022)

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Managing Muscle Loss and Supporting Metabolism One of the biggest concerns with rapid weight loss is muscle loss

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