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Kosinski and colleagues constructed a variant of OXM, OXMQ3E, that was unable to activate the GCGR by changing the third amino acid residue from neutral glutamine to acidic glutamate (38)

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All of this also shouldnt be super surprising

These are not weight-loss results in themselves, but they represent the program establishing its foundation

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However, this landscape could shift next year with the anticipated approval of: The oral version of Wegovy for obesity treatment (approved just yesterday) Eli Lillys Orforglipron