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26 BolyenERideoutJRDillonMRBokulichNAAbnetCCAl-GhalithGAet al

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The platform enables several strategic opportunities, including the following: Lifecycle extension and differentiation Improved benefit-risk profile Scalable platform across CNS indications Building on a validated nose-to-brain platform The new in vivo study results build on MetP Pharmas extensive preclinical body of evidence demonstrating rapid and sustained CNS exposure of GLP-1based therapeutics using its proprietary nasal technologies

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