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While gastrointestinal side effects remained the most common adverse events, including nausea, vomiting, and diarrhea, the overall safety profile was broadly similar to existing incretin-based therapies

Published meta-analyses and systematic reviews indicate that both oral and injectable GLP-1 RAs delay gastric emptying, but the magnitude of this effect is similar across formulations when matched for agent and dosing schedule

Research in some areas remains inconclusive, but many therapeutic uses are already well-established

Patients should be counselled that if they develop symptoms of pancreatitis they should consult a health professional for assessment

Several pharmaceutical companies are actively exploring future opportunities in this space

The clinical significance is uncertain