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Using an integrated ligand and structure-based virtual screening pipeline, explicitly combining complementary ligand-based descriptors, multi-fingerprint similarity, electrostatic similarity, pharmacophore modeling, and multi-conformation docking under a consensus-driven selection strategy, we were able to identify three chemically distinct classes of GLP-1R agonist candidates: GQB47810, a non-peptidic molecule

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muciniphilas mode of action in enhancing the gut barrier function and promoting health, we reasoned that secreted components or cell envelope components of A

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![Figure][1] ### Competing Interest Statement The authors have declared no competing interest

Braz J Biol