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Indias drug regulator steps up action against unauthorised sale and promotion of GLP-1 weight-loss drugs, warning of health risks and tightening inspections across pharmacies and online platforms.

It includes three products

A 90-day self-assessment form lets weight loss patients sell themselves on the next program

Our functional and structural data suggest that receptor conformational dynamics associated with flexibility of the peptide N-terminal activation domain may be a key determinant of agonist efficacy

The FDA also raised concerns about contamination, incorrect dosages, unapproved or harmful ingredients, and counterfeit components in compounded GLP-1s

Finally, we demonstrate that in mice, both the efficacy and tolerability of GLP1R agonists vary with the phase of the estrous cycle, being highest during proestrus (when estrogen levels peak) and lowest in diestrus (low estrogen levels)