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186,187 Besides, previous studies have also emphasized the emerging roles of obesity and metabolic syndrome in pathogenesis of SNS overactivity and cardiovascular diseases, as well as upregulation of SGLT-2 and its activity

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Excluding these two cases (n=6), insulin dose reduction over 1 year was significant (p =0.044) at 12 months (-44 66 units per day) but with no significant difference when assessed by units/kg (p=0.158, ns)