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As compared to mono or coagonists, the triagonist had enhanced effectiveness to decrease body weight and fat mass in rodents

Alcohol independently irritates the stomach lining and can trigger or worsen nausea, vomiting, reflux, and dehydration

After a 5-hour fast, mice were administered water or sitagliptin at 14 g/mouse (gut-selective dose) or 10 mg/kg (systemic DPP-4 inhibition) by gavage

Eating during the day inhibits bone resorption but increases bone resorption at night, and this daytime suppression is eliminated by fasting, further affirming the role of the gut hormones in the control of bone homeostasis

The findings were independent of overweight/obesity category at baseline, as seen in this subgroup analysis for the primary endpoint