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The primary outcome of the study, as in the prior open clinical trial, 46 was the severity of PD motor symptoms by using the MDS-UPDRS part 3 in the Practically defined OFF medication state at the 60-week time-point

Batista AF, Forny-Germano L, Clarke JR, et al

In parallel, GLP-1 receptor agonists have demonstrated neuroprotective actions beyond their established metabolic benefits, offering a promising avenue for cognitive preservation in at-risk individuals

Executive Summary Written by Jonathan Wright, British Clinical Pharmacist Last reviewed: February 2026 Glucagon-like peptide-1 (GLP-1) receptor agonists including semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro) have transformed the treatment of obesity and type 2 diabetes

NoGLP-1 injections use thinner 31-gauge needles compared to standard insulin needles, which means less skin resistance and reduced pain during insertion

