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Factors like baseline weight, age, gender, and genetic differences in GLP-1 receptors play a role in these variations

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Figure 1 Table 1 Effects of GIP receptor agonism or antagonism on glycemic control, body weight, and energy balance in animal models of obesity and diabetes (modified according to Campbell and Nauck) (47, 49)

Therefore, these studies demonstrated that GLP-1RAs have an impact on preventing and stabilizing atherosclerotic vascular disease, which may translate into its protective effects against MACE in human subjects [59]

N Engl J Med 2020

Conclusions and future directions This study provides a comprehensive evaluation of gastrointestinal adverse events associated with GLP-1 RAs in non-diabetic individuals with overweight or obesity