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Enhanced insulin signaling following weight loss has been associated with decreased circulating levels of pro-inflammatory cytokines, including IL-6, TNF-, and C-reactive protein, as well as improvements in endothelial and adipose tissue function ( In inflammatory arthritis, including PsA, improved insulin sensitivity has been independently associated with reduced disease activity and inflammatory burden, even after adjustment for changes in BMI ( Consistent with this concept, GLP-1RAs have been shown to directly modulate immune responses by reducing the secretion of key pro-inflammatory cytokines such as IL-6 and TNF-, which are central drivers of inflammation in both PsO and PsA ( 3.4 Early PsA and future research directions Despite the promising metabolic and immunomodulatory effects observed in PsO, the role of GLP-1RAs in PsA, particularly in its early stages, remains largely unexplored

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[4] This reduction can happen rapidly and as a result, certain nutrients are at risk of being at a deficiency

From 2018 to 2021, patient volume for anti-obesity therapies increased by 16.4%, compared to 94.5% from 2021 to 2024, following the approvals of #Wegovy in June 2021 and #Zepbound in November 2023