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Current management of DKD centres around four key pillars of guideline-directed medical therapy (GDMT): reninangiotensinaldosterone system inhibitors, sodium-glucose cotransporter-2 inhibitors, non-steroidal mineralocorticoid receptor antagonists and glucagon-like peptide-1 receptor agonists

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Interestingly, GCG was also shown to bind the GLP-1R, although it has about 140 times less affinity for GLP-1R than the specific agonists of these receptors (Chepurny et al

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The authors disclosed none

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included at least one ICD code for T2D (Supplemental Table 1)

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