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Semaglutide, as a medication, may cause side effects like nausea or digestive discomfort but is clinically tested and widely used for weight management

That is not the issue

FGF21 exerts further anti-inflammatory effects by stimulation of adiponectin, which can enhance lipid and glucose metabolism and therefore mitigate the risk of obesity, diabetes and ASCVD [89]

However, a more recent RCT of 255 adults with nicotine dependence did not show any effect of adjunctive dulaglutide compared with standard of care (that is, behavioral counseling with varenicline) on cigarette abstinence over 12 weeks of treatment 117

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