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The EU health claim under Regulation 432/2012 references a minimum of 20 g (approximately 1.5 tablespoons) per day for oils containing at least 250 mg/kg of hydroxytyrosol and its derivatives

This requirement contradicts clinical evidence showing that traditional diet-and-exercise approaches produce 5-7% average weight loss compared to 15-20% with GLP-1 therapy-yet insurers mandate failure before approving effective treatment

Disease modifying agents capable of controlling obesity with meaningful metabolic improvement have reshaped expectations for both clinicians and patients ( Nausea and vomiting remain among the most frequent and disruptive adverse effects across Glucagon-like peptide (GLP-1)-based therapies ( In this opinion article, we examine the mechanisms underlying nausea and vomiting in semaglutide, CagriSema, survodutide, tirzepatide, retatrutide, and orforglipron and situate them within obesity clinical practice ( We also propose practical strategies to mitigate gastrointestinal intolerance

Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of incretin-based therapies for the management of hyperglycemia and, in some cases, cardiovascular risk in people with type 2 diabetes

At lower starting doses the effect may not last a full 7 days but as your dose increases through titration, appetite control becomes more consistent across the week

It allows Novo to defend its semaglutide franchise while broadening access to patients who prefer oral therapy