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Endothelial cells (ECs) covering the inner surface of the vascular wall can generate, activate, and release various vasoactive substances and regulate cardiovascular function, including nitric oxide (NO), prostacyclin (PGI2), endothelin-1 (ET-1), and endothelium-derived contracting factors (EDCF)

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The first among long-acting novel amylin analogs is cagrilintide, which was discovered in 2021

3ac and Extended Data Fig

It is well established that the apoptosis-induced follicular atresia of the granulosa cells (GCs) is also a key component of the failure in the dominant follicle selection [41]