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Once-weekly dosing therefore produces sustained drug concentrations that are an order of magnitude or more above physiologic baseline

The SURPASS trials reported reductions in HbA 1C ranging from 20.4 mmol/mol (5 mg tirzepatide s.c

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[1] [2] This consistent dosing schedule is designed to maintain steady therapeutic levels of tirzepatide in the body, ensuring optimal glycaemic control throughout the week

People lose weight at different rates, which makes it difficult to say concretely when a person can expect to see their target number on the scale