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Darker lines are used for the larger subgroups

Cardiovascular improvements The SELECT trial gave us the biggest breakthrough yet

10.2337/dc14-2883 17 DaviesM.FrchL.JeppesenO

[2] Mazdutides phase II trial in adults with obesity or excess weight showed approximately 10-14% weight loss at 4 mg and 6 mg doses over 32 to 48 weeks, with ongoing phase III trials investigating higher doses and effects on type 2 diabetes

Several hormones have been shown to regulate intestinal and hepatic lipid metabolism such as insulin and gut-derived incretin hormones released upon nutrient consumption [50, 107]

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