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The authors also suggest a second potential pathway independent of GLP-1 for some of the cardiovascular effects

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As a member of the type II transmembrane proteins, DPP4 contains a typical signal peptide, which is necessary for the targeting to the endoplasmatic reticulum and the initiation of the translocation across the cell membrane

Baker WL, Smyth LR, Riche DM, Bourret EM, Chamberlin KW, White WB

Another mechanism linking nutrient sensing to the rise in postoperative GLP-1 is the increase in plasma bile acids seen with both RYGB and VSG
