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GLP-1 increased the expression of the mitochondrial protective gene (PGC-1)

This underlines the importance of both the GLP-1R and GLP-1 itself for cocaine intake

In mice with DSS-induced colitis, treatment with 3.6 M Amuc_1409* per day induced body weight gain, increased colon length and lowered the histopathological score in the distal colon

Tirzepatide (Zepbound, Mounjaro) Tirzepatide works similarly to semaglutide, but in addition to mimicking GLP-1, tirzepatide also mimics the hormone GIP (which stands for glucose-dependent insulinotropic polypeptide)

despite being taken as a daily pill rather than injection, it contains the same active ingredient and allegedly carries similar risks Mounjaro (tirzepatide): Manufactured by Eli Lilly and approved in May 2022, this medication works as a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist, offering enhanced blood sugar control and weight loss effects but also allegedly causing severe gastrointestinal injuries similar to semaglutide products Trulicity (dulaglutide): Eli Lillys once-weekly GLP-1 injection approved in 2014 for type 2 diabetes