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An additional manual search of bibliographies of articles meeting study inclusion criteria was conducted to ensure the comprehensiveness of the literature

The microdosing schedule may be prescribed as follows: Weeks 14: 1.0 mg once weekly Weeks 58: 1.5 mg once weekly Weeks 912: 2.0 mg once weekly Week 13 and beyond: Transition to the standard 2.5 mg dose, then proceed with the standard escalation plan

Fiber consumption while using GLP-1RA from food sources averaged 14.5 g, significantly below the daily recommendations of 2538 g per day [18]

It is important to note that these values are based on the human GIPR (hGIPR), while tirzepatide is much less potent (30100-fold reduced) at the mouse GIPR (mGIPR) 45

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Even simple things like taking the stairs instead of the escalator or elevator can make a difference.