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The most common side effects for both injectable and oral forms of semaglutide (Wegovy) include gut issues, such as nausea, vomiting, diarrhea, and constipation, said Hamlet Gasoyan, PhD, assistant professor of medicine at Cleveland Clinic Lerner College of Medicine

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These are common and are not much cause for concern

States including Idaho and Tennessee have announced investigations into illegal dispensing by medical spas and other providers, while states such as California are looking to beef up their oversight

For maximum weight loss efficacy , injectable tirzepatide remains the top choice

Studies of orforglipron (Foundayo) showed significant and sustained weight loss (at least 10% of starting weight) over 72 weeks