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Description

This process is called titration and it exists to give your body time to adjust, which helps reduce side effects like nausea and stomach discomfort

Zepbound (tirzepatide) is a dual GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 receptor agonist-the first and only approved treatment activating both incretin hormone receptors

They were originally developed for management of type 2 diabetes, but have since become a common treatment for weight management within the UK

Genetic evidence, such as GWAS, has identified the single-nucleotide polymorphism (SNP) in GIPR, showing that lower function of GIPR is associated with lower BMI ( On the other hand, chronically elevating GIP levels in a transgenic mouse model exhibited reduced diet-induced obesity ( To reconcile the findings that both GIPR antagonists and GIPRAs reduce body weight, it is possible that physiological GIPR activity plays a permissive role in adipose tissue synthesis, while pharmacologically enhanced GIPR activity may reduce body weight through a different mechanism in the brain