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Key variants like GLP1R rs6923761, GIPR rs1800437, FTO rs9939609, and MC4R rs17782313 influence semaglutide efficacy and side effect tolerance

This occurs through multiple mechanisms: increased aromatase activity in adipose tissue converts testosterone to estrogen, inflammatory markers suppress testicular function, and altered leptin signaling impairs the hypothalamic-pituitary-gonadal axis

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However, this can worsen optic nerve perfusion, he said

doi: 10.4103/BC.BC_21_21