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Side effects may temporarily increase with each dose escalation and then subside as adaptation occurs

While the Phase 2 trial did not specifically stratify outcomes by baseline eGFR, GLP-1 receptor agonists as a class have demonstrated renoprotective effects in at-risk populations

Room Temperature Storage : If needed, an unopened pen may be stored at room temperature (up to 86F or 30C) for up to 21 days before use

However, Retatrutide is still in the research phase and is not approved for general use

Both Mounjaro and Zepbound, approved as pre-filled sterile single-dose pen injections, were added to the FDA drug shortage list within a few months of their initial approvals