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Nanostructured lipid carriers have poor stability, are prone to lipid crystallization, and have a complex formulation process that is difficult to apply widely

Crucially, this elevation was not a brief spike

Specifically, oxygen consumption enables to meet increased energy demands in neural circuits by facilitating oxidative phosphorylation in the mitochondria and thus, contributing to the generation of adenosine triphosphate (ATP) 14,55,56

277 The phosphorylcholine polymer exhibited long-lasting circulation and achieved higher accumulation in brain tumor tissue, serving as an effective tool for BBB crossing

doi: 10.1073/pnas.2005615117 141 YangS

Common adverse effects include tachycardia, arrhythmias, and hypertension, and use is contraindicated in patients with idiopathic hypertrophic subaortic stenosis (IHSS), requiring careful monitoring during therapy