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[6] [7] The GIP component may complement GLP-1 activity by supporting insulin secretion and potentially influencing fat metabolism, though the precise contribution of GIP agonism in humans remains an area of active research and the evidence is not yet fully established

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To examine possible associations with morbidity, we compared differences in comorbidities between obesity classes

Patients who have been on GLP-1 therapy for 3+ years and have significant collagen depletion

A 17-month study specifically looking at its effect on obesity showed people on the highest dose of tirzepatide (15 milligrams) lost on average just over 20% of their body weight

(28) The crude incidence rates of amputation were 6.1 per 10,000 person-years for GLP-1s, 1.5 for SGLT-2 inhibitors, 4.6 for DPP4-Is, and 1.9 for other agents