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Tirzepatide functions as both a glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonist

Exenatide treatment was associated with a prolonged increase of phosphorylation of insulin receptor signaling substrate-1 (IRS1) phosphorylated at tyrosine residues at 24, 48, and 60 weeks

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