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The receptor question is itself contentious: integrin V5 has been proposed as a functional receptor mediating irisin effects on bone and adipose tissue, and V3 integrin has been implicated in neuroprotective effects, yet neither has been universally accepted as a bona fide irisin receptor, and the binding affinities reported vary across experimental systems (Kim et al., 2018

Sally Seymour, director of the Division of Pulmonology, Allergy, and Critical Care in the FDAs Center for Drug Evaluation and Research, said in a news release

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Prevalence of hypogonadism in males aged at least 45 years: the HIM study

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