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210,216,217 A randomized placebo-controlled trial in 100 heart disease patients found 450 mg of pomegranate extract plus 180 mg vitamin E (as synthetic dl-alpha tocopherol) daily for eight weeks reduced expression of two vascular adhesion proteins and lowered levels of inflammatory markers

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NAD+ supports metabolism, DNA repair, cell defenses, circadian rhythm coordination and other cellular processes which leads to better quality of life

Darker urine may indicate dehydration

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( 13 ) Its also important to avoid unnecessary supplementation