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These effects were more pronounced in high-alcohol-consuming animals, and microinjection into the VTA confirmed a critical role of mesolimbic GLP-1Rs

This influx of Ca 2+ then triggers exocytosis of insulin-containing granules

demonstrated no difference in either plasma or tissue concentrations of meal stimulated GLP-2 between patients with IBD and non-IBD controls (Schmidt et al

Nevertheless, insofar as the physiological, postprandial GLP1 release from L cells is concerned, gutderived GLP1 might not reach the CNS at all, but primarily acts locally in a paracrine fashion, activating GLP1 receptors in the vicinity of the intestinal system (Richards et al., 2014)

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