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Description
It targets GLP1, GIP, and glucagon receptors simultaneouslyhence the third generation label after single (Ozempic) and dual (Mounjaro) agonists
Effects of incretin hormones on beta-cell mass and function, body weight, and hepatic and myocardial function

In humans, GLP-1R immunoreactivity has been detected in T cells by flow cytometry, including in invariant natural killer T (iNKT) cells (43), PBMC T cells (36), and chimeric antigen receptor (CAR) T cells (44)

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Needle phobia affects an estimated 20-30% of the adult population, and the logistics of cold-chain storage, injection site management, and weekly self-administration limit the reach of these therapies to a fraction of the eligible patient population

Diabetes care, 38(6), 10581066
