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The hepatic TGF-/Smad signaling pathway was downregulated by SEMA treatment, while sirtuin 1 (SIRT1) content and phosphorylated AMP-activated protein kinase (p-AMPK) expression were upregulated

RETA induced immune reprogramming systemically and in the tumor microenvironment with durable anti-tumor immunity evidenced by elevated circulating IL-6, increased antigen presenting cells, reduced immunosuppressive cells, and activation of pro-inflammatory pathways

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