what are natural glp 1 agonists GLP-1 for Weight Loss: Safe or Risky? Trends in the Development of

IH has received grants from AstraZeneca/Bristol Myers Squibb, Eli Lilly, GlaxoSmithKline, Janssen, Lexicon Pharmaceuticals, Medtronic, Merck & Co., Novo Nordisk, the Population Health Research Institute and Sanofi

In a cohort study of individuals with T2D and metabolic-associated fatty liver cirrhosis (459 GLP-1RA users), GLP-1RA therapy was associated with reduced risks of hepatic decompensation, portal hypertension, hepatocellular carcinoma, and liver transplantation (111)

Biggest breakthrough since statins GLP-1s are classed as receptor agonists, or drugs that activate at specific receptors in the body

By slowing down digestion, more gastrointestinal side effects can occur, including: Nausea Vomiting Diarrhea Constipation Bloating Indigestion Abdominal discomfort Sulfur burps (foul, rotten-egg-smelling burps) Acid reflux Why Side Effects Peak During Titration Medication can affect everyone differently, and so people may experience various side effects at different times while taking a drug, depending on their dosage and other factors

2 With the use of GLP-1 receptor agonists becoming increasingly more common, anesthesia professionals need to be aware of these medications and the potential risks they pose to patients receiving anesthesia

Following oral nutrient intake, GLP-1 is secreted from intestinal L-cells located in the ileum and colon