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GLP-1 Agonists and Mechanistic Rationale Preclinical Data: Inflammation, Oxidative Stress, Mitochondrial Function Emerging research in animal models of PD suggests that GLP-1RA may hold promise in addressing the underlying mechanism and symptoms associated with PD

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[2] Since then, several other GLP-1 agonists have been developed and approved for clinical use, including liraglutide (Victoza), dulaglutide (Trulicity), semaglutide (Ozempic and Wegovy), and Tirzepatide (Mounjaro and Zepbound)

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The short circulating half-life ( t 1/2 ) of native GLP-1 (1 minute) makes it unfit as a therapeutic agent, and longer-acting GLP-1RAs with half-lives ranging from 2.5 hours to more than a week have been developed for the treatment of both type 2 diabetes and obesity (Table 1) (18)

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