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Notably, given that SGLT-2 is expressed in the brain, which is consistent located with enhanced cFos expression induced by SGLT-2is, we hypothesize that SGLT-2is may cross the BBB via receptor-mediated transcytosis

The Wegovy pill was approved by the Medicines and Healthcare products Regulatory Agency (MHRA) on 11 June 2026 as an oral GLP-1 receptor agonist licensed for weight management in Europe

However, the side effects profile mainly depends on an individuals tolerance, body metabolism, genetics, lifestyle habits, and health conditions

Avoiding high-fat or greasy foods during the adjustment period also helps

But note, not everyone experiences the large amounts of weight loss from GLP-1 RAs you may have heard about

Dietary changes : Patients starting GLP-1 therapy often make significant dietary modifications, including increased vegetable and fruit consumption (which have high water content) and reduced processed food intake