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27 Investigators evaluated the safety, efficacy, and tolerability of three therapies when added to metformin: exenatide (Byetta, Amylin), sitagliptin, and pioglitazone

In a Phase 1 clinical trial, AMG133 demonstrated significant dose-dependent weight loss effects, achieving up to a 14.5% reduction in body weight compared to a 1.5% reduction for the placebo group on day 85

Modeling endoscopic improvement after induction treatment with mesalamine in patients with mild-to-moderate ulcerative colitis

But, Gulliver-Garcia points out, shes on another medication that makes her gain weight, which can make results different than what others might experience

For example, metabolic optimization with a GLP-1RA first can be contrasted with immediate ovulation induction/IVF with respect to expected trade-offs in live birth, OHSS risk, pregnancy complications, and longer-term metabolic benefits

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