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These acute effects occur within hours and precede any meaningful weight loss

In other words: Receptor overstimulation from rapid dose increases is the primary driver of gastrointestinal adverse events, not the compound itself when used therapeutic doses

54 BMI as a metric of obesity has some limitations, such as not being able to differentiate between lean and fat mass, estimate the magnitude of visceral obesity and predict outcomes

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Bridging the gap between findings in animal models and human applications is a critical step toward achieving clinical success