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This 'off-label' usage isn't ideal

These acute effects occur within hours and precede any meaningful weight loss

In this randomized clinical trial, scientists have investigated whether a combination of a 5:2 intermittent fasting diet and a meal replacement diet can effectively control blood glucose levels and reduce body weight in obese or overweight Chinese adults with early type 2 diabetes

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[6] [7] The GIP component may complement GLP-1 activity by supporting insulin secretion and potentially influencing fat metabolism, though the precise contribution of GIP agonism in humans remains an area of active research and the evidence is not yet fully established

In fact, we often recommend combining these therapies