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An entrepreneur I met in a Substack comment thread about GLP-1s said he heard of associates in high-risk finance jobs underperforming because they are no longer as impulsive

Cottone: GLP-1 is a hormone that stimulates the release of insulin from the pancreatic islets and curbs hunger, among other actions

Clinical trials have shown that tirzepatide can lead to an average weight loss of 15 to 20% depending on the dosage, which is slightly higher than the results seen with semaglutide, where weight loss typically ranges between 10% and 17%

Several people had tried them, with some reporting positive changes

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Both are excellent in their craft and amazing in their bedside manner