semaglutide + tirzepatide Semaglutide/Tirzepatide: Beyond Weight Loss: Shamsah Amersi, MD: OB-GYNs Semaglutide vs. Tirzepatide: What's the

GLP-1RAs provide cardioprotective benefits through glycaemic and non-glycaemic effects, including improved insulin secretion and action, body-weight loss, blood-pressure lowering and improved lipid profile, as well as via direct effects on the heart and vasculature

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Although total lean mass (baseline 51.3 kg) was also reduced by 2.3 kg and 1.5 kg with semaglutide and canagliflozin, respectively (estimated treatment difference: 0.78 [1.61, 0.04]), the proportion of lean mass (baseline 59.4%) increased by 1.2%- and 1.1%-point, respectively (estimated treatment difference 0.14 [0.89, 1.17])

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The question is whether we'll build a system that actually uses them

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