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Empagliflozin crosses the placenta and reaches fetal tissues in rats

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These can include: Nausea, vomiting, or bloating Constipation, diarrhoea, or stomach discomfort Indigestion or heartburn Loss of appetite Feeling tired or weak Headache Redness, swelling, itching, or pain at the injection site Rarely, lumps or scarring may occur if injections are not rotated In rare cases, more serious risks can occur and may require immediate medical attention

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In brain, the primary locus of GLP-1 production is in the caudal nucleus of the solitary tract (NTS) and the ventrolateral medulla of the hindbrain
