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468 In a clinical trial investigating the safety of tofacitinib, UC patients treated with tofacitinib for 16 weeks (10 mg BID) did not experience significant adverse effects

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Even though more than 50% of patients experienced side effects, mainly gastrointestinal symptoms, it required stopping semaglutide use or dose mitigation in only ~16% of the patients, showing that this drug is well-tolerated, which is crucial for chronic weight management

Switching from an injectable to an oral GLP-1 requires some adjustments, especially around timing and routine