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Description
1 Introduction Inflammatory bowel disease (IBD), comprising Crohns disease (CD) and ulcerative colitis (UC), is a multifactorial, chronic, immune-mediated inflammatory disorder that affects the gastrointestinal system

In 1967 Steiner showed that insulin was synthesised from a precursor protein, called proinsulin

In a study of semaglutide efficacy, the average reduction in weight from baseline was 10.2%, but 4.9% of patients achieved over 25% reduction from baseline, and 32.2% achieved less than a 5% reduction from baseline or even weight gain 5

Their current strategy is to contain near-term expenses while waiting for clearer long-term data and possible price competition (including generics or biosimilars)

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Biological Mechanisms Behind Mood Changes on GLP-1 Therapy GLP-1 receptors exist throughout the brain, including regions involved in mood regulation, reward processing, and stress response
