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In nonneuronal tissues, experimental studies have demonstrated that melatonin inhibits NO production induced by lipopolysaccharide (LPS) that induce the activation of the immune response 77

NAFLD is associated with several comorbidities, including type 2 diabetes (T2D), cardiovascular diseases (CVD), and chronic kidney disease (CKD) 5

Effects of Efpeglenatide versus liraglutide on gastric emptying, glucose metabolism and beta-cell function in people with type 2 diabetes: an exploratory, randomized phase Ib study

Phase 2 clinical trial data published in the New England Journal of Medicine in 2023 demonstrated substantial mean reductions in body weight in some participants exceeding 20% over 48 weeks alongside improvements in glycaemic control and cardiometabolic markers
Lundqvist A, Steen Carlsson KP, et al

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