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42 AUTHOR CONTRIBUTIONS KKS contributed to conceptualization, methodology, data curation, formal analysis, and original draft preparation

SSZ and RAM provided senior author input in the design of the study and review of the manuscript, and UA oversaw the study development, manuscript writing, provided senior author review of the manuscript and is the guarantor of this work

When FXR is inhibited, intestinal stem cells generate more L-cells, which produce GLP-1

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To combat this, semaglutide drugs mimic a natural hormone in the body known as glucagon-like peptide 1 (GLP-1)

Weight measurements were entered in the app by the participants themselves (ie, self-reported), which we triangulated where possible with additional documentation such as progress photographs