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In a 72-week study enrolling 3,172 overweight adults, the highest dose of orforglipron (36 mg) caused 12.4% weight loss

However, these concerns are controversial in clinical trials

Indeed, Garvey et al

Clinicians managing lupus patients on GLP-1 medications have reported successful prednisone tapers that were previously difficult or impossible

ANS (8) : Refer Table 1 below: Table 1: Basic tests and reasons for monitoring drug actions NOTE : If the patient develops severe upper abdominal pain, nausea, or yellowing of the eyes while on these medications, it is necessary to consult a physician immediately

doi: 10.1056/NEJMc2406233