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Summary Although GLP-1R agonists were originally developed for glycemic control in DM, their mechanistic versatility has enabled broader application across a spectrum of cardiovascular, cerebrovascular and metabolic disorders

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Lifestyle therapies for obesity have often shown small short-lived benefits, and there has been a chronic dearth of effective pharmaceutical choices for the treatment of obesity (9)

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Identifying these reasons is essential for optimising treatment outcomes

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While there is no official clinical guidance supporting this practice, individual tolerance patterns vary, and patients should discuss timing strategies with their healthcare provider if side effects are problematic

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